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M94A0258.TXT
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1994-10-08
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Document 0258
DOCN M94A0258
TI Predictors of survival in patients with AIDS and disseminated
Mycobacterium avium complex disease.
DT 9412
AU Horsburgh CR Jr; Metchock B; Gordon SM; Havlik JA Jr; McGowan JE Jr;
Thompson SE 3rd; Department of Medicine, Grady Memorial Hospital,
Atlanta,; Georgia.
SO J Infect Dis. 1994 Sep;170(3):573-7. Unique Identifier : AIDSLINE
MED/94358490
AB Patients with AIDS and disseminated Mycobacterium avium complex disease
(DMAC), as defined by the presence of a positive blood culture for MAC,
were studied retrospectively to define the natural history of DMAC. All
patients had fevers, severe anemia (hematocrit < 26%), or both.
Eighty-seven (76%) had signs, symptoms, or laboratory findings related
to the gastrointestinal tract, but no distinct syndrome was identified.
Sixty-nine patients received antimycobacterial therapy; assignment to
therapy was not randomized. In a proportional hazards analysis, shorter
survival was associated with higher initial level of mycobacteremia
(relative risk [RR], 1.86; 95% confidence interval [CI], 1.49-2.31; P <
.001), while administration of antimycobacterial chemotherapy (RR, 0.42;
95% CI, 0.26-0.70; P < .001) and antiretroviral therapy (RR, 0.40; 95%
CI, 0.22-0.73; P < .01) had protective effects. Thus, the initial level
of mycobacteremia of patients with DMAC may have prognostic value, and
administration of antimycobacterial and antiretroviral agents may be
associated with prolonged survival.
DE Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY Adult
Antibiotics/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/*MORTALITY/PHYSIOPATHOLOGY Bacteremia/EPIDEMIOLOGY Female
Human Male Multivariate Analysis Mycobacterium avium-intracellulare
Infection/*MORTALITY/ PHYSIOPATHOLOGY Predictive Value of Tests
Prognosis Proportional Hazards Models Risk Factors Survival Analysis
Survival Rate JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).